Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow

Autor: Kaylie Sampson, Songmi Koo, Carter Gadola, Anastasiia Vasiukhina, Aditya Singh, Alexandra Spartano, Rachana Gollapudi, Matthew Duley, Jens Mueller, Paul F. James, Amy M. Yousefi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: SN Applied Sciences, Vol 3, Iss 12, Pp 1-17 (2021)
Druh dokumentu: article
ISSN: 2523-3963
2523-3971
74497855
DOI: 10.1007/s42452-021-04871-3
Popis: Article highlights A design of experiments to generate 16 scaffold architectures and compositions, featuring both micropores and macrochannels, so as to provide an ideal environment for bone regeneration; The step-by-step fabrication process, examining the internal structures, and the simulation of fluid flow (COMSOL) to supply adequate mechanical stimulation during bioreactor cultivation; The DNA content for the cell-seeded scaffolds over time (culture dish vs. a bioreactor), compared with a commercial scaffold featuring a similar porosity and pore size range.
Databáze: Directory of Open Access Journals
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