Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior
| Autor: | Ángela Velasco, Julia Rodríguez-Revuelta, Emilie Olié, Iciar Abad, Abel Fernández-Peláez, Aurélie Cazals, Sébastien Guillaume, Lorena de la Fuente-Tomás, Luis Jiménez-Treviño, Laura Gutiérrez, Paz García-Portilla, Julio Bobes, Philippe Courtet, Pilar A. Sáiz |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 63 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2019.20 |
| Popis: | AbstractBackground.Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have emerged as important peripheral inflammatory biomarkers. Recent data suggest a possible role of the immune system in the pathophysiology of suicidal behavior (SB). The aim of this study is to evaluate the association among NLR, MLR, and PLR and SB in patients with major depressive disorder (MDD), and to test its validity as a biomarker for suicidality.Methods.We evaluated 538 patients with MDD (mean age [standard deviation] = 43.87 [14.36] years; females: 68.8%). A logistic regression model was estimated to determine the independent factors associated with suicide risk in patients with and without a history of suicide attempt (SA).Results.Three hundred ninety-three patients (74.7%) had a personal history of SA. Patients with a previous SA were more frequently female (71.9% vs. 59.6%; p = 0.007), significantly younger (41.20 vs. 51.77 years; p |
| Databáze: | Directory of Open Access Journals |
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