The Effectiveness of Post-Vaccination and Post-Infection Protection in the Hospital Staff of Three Prague Hospitals: A Cohort Study of 8-Month Follow-Up from the Start of the COVID-19 Vaccination Campaign (COVANESS)
| Autor: | Marek Petráš, Ivana Králová Lesná, Livia Večeřová, Elka Nyčová, Jana Malinová, Petr Klézl, Martina Nezvedová, Rachel Elizabeth White, Roman Máčalík, Jana Dáňová, Alexander M. Čelko, Věra Adámková |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Vaccines, Vol 10, Iss 1, p 9 (2021) |
| Druh dokumentu: | article |
| ISSN: | 10010009 2076-393X |
| DOI: | 10.3390/vaccines10010009 |
| Popis: | Continuous assessment of the effectiveness of approved COVID-19 vaccines is crucial to gain an insight into the longer-term impact on health outcomes, and eventually boosting public confidence. For this reason, we conducted a multicenter, retrospective cohort study using data on infection and vaccination rates among employees of three Prague hospitals in the period between 27 December 2020 and 31 August 2021. The post-vaccination and post-infection protectiveness were assessed in a total of 11,443 hospital workers who were followed up for more than 14 days either after their Comirnaty vaccination or study enrolment, depending on their previous SARS-CoV-2 infection. The effectiveness of full vaccination against any SARS-CoV-2 infection achieved 88.3% (83.2–91.8%) over the eight months of follow-up, a figure not much different from the 92.5% (76.5–97.6%) level of protection built by a previous infection. Despite this, the post-vaccination level of protection declined to about 65% between June and August. No case of breakthrough infection was registered among hospital workers having received one or two vaccine doses more than three months after previous infection. The eight-month effectiveness of the Comirnaty vaccine exhibited a declining trend requiring a new booster dose. The need for vaccination in the previously infected employees was not demonstrated conclusively in this study. |
| Databáze: | Directory of Open Access Journals |
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