| Autor: |
Elvira Bailón, Juan Román, Isabel Ramis, Pedro Michelena, Dolors Balsa, Manuel Merlos, Antonio Zarzuelo, Julio Gálvez, Mònica Comalada |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 315-318 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.08292SC |
| Popis: |
The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 μM) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)-activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation. Keywords:: inflammatory bowel disease, B lymphocyte, Th2-cytokine |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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