STUDY OF INDOLE SS-68 DERIVATIVE IMPACT ON THE PRIMARY GENERALIZED CONVULSIONS INDUCED BY MAXIMAL ELECTRIC SHOCK, THIOSEMICARBAZIDE AND PILICARPINE
| Autor: | S. K. BOGUS, I. G. COVALEV, O. N. GULEVSKAYA, K. F. SUZDALEV, P. A. GALENKO-YAROSHEVSKY |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Кубанский научный медицинский вестник, Vol 0, Iss 3, Pp 17-21 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1608-6228 2541-9544 |
| DOI: | 10.25207/1608-6228-2017-24-3-17-21 |
| Popis: | Aim. Study of SS-68 impact on primary generalized convulsions in basic estimation tests of anticonvulsant action of agents.Material and methods. Study of the SS-68 impact on primary generalized convulsions included an estimation of anticonvulsant action with maximal electric shock, thiosemicarbazide and pilocarpine antagonism tests performed on white outbred male mice and rats.Results. SS-68 compound possesses dosage dependent anticonvulsant action in maximal electric shock test indicating its ability to prevent death of 100% animals and its activity in thiosemicarbazide and pilocarpine antagonism tests as well. In the maximal electric shock test SS-68 surpassed sodium valproate in its anticolvulsant activity.Conclusion. Neurotransmitter systems of the brain such as GABA, cholinergic and amino acid stimulant system as well as K+, Na+ and Ca2+ channels of neurons shall be the most possible molecular targets of SS-68 anticonvulsant action. Higher activity of SS-68 comparing with sodium valproate in the maximal electric shock test (increasing GABA content in central nervous system) can be related with its wide range of neurotropic action. |
| Databáze: | Directory of Open Access Journals |
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