Autor: |
Alla I. Vaskevych, Nataliia O. Savinchuk, Ruslan I. Vaskevych, Eduard B. Rusanov, Oleksandr O. Grygorenko, Mykhailo V. Vovk |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2787-2794 (2021) |
Druh dokumentu: |
article |
ISSN: |
1860-5397 |
DOI: |
10.3762/bjoc.17.189 |
Popis: |
A regioselective method for the synthesis of 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones – close structural analogs of naturally occurring vasicinone alkaloids – is described. The procedure is based on PIFA-initiated oxidative 5-exo-trig cyclization of 2-(3-butenyl)quinazolin-4(3Н)-ones, in turn prepared by thermal cyclocondensation of the corresponding 2-(pent-4-enamido)benzamides. The products obtained have a good natural product likeness (NPL) score and therefore can be useful for the design of natural product-like compound libraries. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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