| Autor: |
Peni Lestarini, Endang Astuti, Deni Pranowo |
| Jazyk: |
English<br />Indonesian |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Al-Kimia, Vol 7, Iss 1, Pp 25-32 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2302-2736 |
| DOI: |
10.24252/al-kimia.v7i1.6340 |
| Popis: |
Abstract Cytotoxic activity of ethanol and n-heksana extract temu kunci (Kaempferia pandurata) rhizome and its effect to p53 and bcl-2 genes expression on Raji cell line had been carried out. The rhizome of K. pandurata was drained and extracted using ethanol and n-heksana as the solvent. The ethanol and n-heksana extract were tested to Raji cell line. The p53 and bcl-2 genes expression were observed by immunocytochemistry method. The result showed that ethanol and n-heksana extract from K. Pandurata had cytotoxic activity to Raji cell line. The IC50 values for ethanol and n-heksana extract were 4.87 μg / mL and 4.14 μg / mL. The ethanol and n-heksana extract from K. Pandurata extract had capability to increase p53 gene expression and decrease bcl-2 gene expression on Raji cell line. Keywords: Kaempferia pandurata rhizome , p53 dan bcl-2 gene expression, raji cell line |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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