| Autor: |
Isamara Carvalho Ferreira, Raíssa Cristina Darroz Côrrea, Sarah Lam Orué, Daniel Ferreira Leite, Paola dos Santos da Rocha, Claudia Andrea Lima Cardoso, Rosilda Mara Mussury, Patricia Vit, Kely de Picoli Souza, Edson Lucas dos Santos, Jaqueline Ferreira Campos |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Antioxidants, Vol 12, Iss 6, p 1276 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2076-3921 |
| DOI: |
10.3390/antiox12061276 |
| Popis: |
Cerumen is a bee product produced exclusively by stingless bees, resulting from a mixture of beeswax and plant resins. The antioxidant activity of bee products has been investigated since oxidative stress is associated with the onset and progression of several diseases that can lead to death. In this context, this study aimed to investigate the chemical composition and antioxidant activity of cerumen produced by the Geotrigona sp. and Tetragonisca fiebrigi stingless bees, in vitro and in vivo. The chemical characterization of cerumen extracts was performed by HPLC, GC, and ICP OES analyses. The in vitro antioxidant potential was evaluated by DPPH• and ABTS•+ free radical scavenging methods, and in human erythrocytes subjected to oxidative stress with AAPH. In vivo, the antioxidant potential was evaluated in Caenorhabditis elegans nematodes subjected to oxidative stress with juglone. Both cerumen extracts presented phenolic compounds, fatty acids, and metallic minerals in their chemical constitution. The cerumen extracts showed antioxidant activity by capturing free radicals, reducing lipid peroxidation in human erythrocytes, and reducing oxidative stress in C. elegans, observed by the increase in viability. The results obtained indicate that cerumen extracts from Geotrigona sp. and Tetragonisca fiebrigi stingless bees may be promising against oxidative stress and associated diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
