Hepatitis B virus-induced CD4 lymphocytopenia: A rare cause of progressive multifocal leukoencephalopathy

Autor:	Amar Kumar Mishra, Sanjay Kumar, Niraja Agasti, Gautam Guha, Saikat Ghosh, Bijendra Mohanty, Pideno S Ngullie, Joydeep Mukherjee
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	progressive multifocal leukoencephalopathy idiopathic cd4 lymphocytopenia human immunodeficiency virus john cunningham virus acquired immunodeficiency syndrome hepatitis b virus polymerase chain reaction translocator protein positron emission tomography Medicine
Zdroj:	Asian Journal of Medical Sciences, Vol 13, Iss 10, Pp 288-292 (2022)
Druh dokumentu:	article
ISSN:	2467-9100 2091-0576
DOI:	10.3126/ajms.v13i10.44407
Popis:	Progressive multifocal leukoencephalopathy (PML) is a rare subacute-onset fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus. It usually occurs in impaired cell-mediated immunity settings such as lymphoproliferative disorders, chronic infective or granulomatous conditions on immunosuppressive medications, and human immunodeficiency virus infection. It also appears very rarely with idiopathic CD4 lymphocytopenia. We present a case of PML with visual field defect, progressive motor impairment, behavioral alteration, and dementia. Magnetic resonance imaging had features of asymmetric non-enhancing hyperintense subcortical white matter lesions in the background of chronic active hepatitis B infection. To the best of our knowledge, this is the first case report of CD4 lymphocytopenia associated PML following chronic hepatitis B infection.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3b8f75cedb244b4f93ebac67b1fef6e3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF