A cross‐sectional study of MRI features and the gut microbiome in pediatric‐onset multiple sclerosis

Autor: Feng Zhu, Yinshan Zhao, Douglas L. Arnold, Amit Bar‐Or, Charles N. Bernstein, Christine Bonner, Morag Graham, Janace Hart, Natalie Knox, Ruth Ann Marrie, Ali I. Mirza, Julia O'Mahony, Gary Van Domselaar, E. Ann Yeh, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett, US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 486-496 (2024)
Druh dokumentu: article
ISSN: 2328-9503
DOI: 10.1002/acn3.51970
Popis: Abstract Objective To identify gut microbiome features associated with MRI lesion burden in persons with pediatric‐onset multiple sclerosis (symptom onset 0.08). At the phylum level, high Tenericutes (relative abundance) was associated with higher T1 and T2 volumes (β coefficient = 0.25, 0.37) and high Firmicutes, Patescibacteria or Actinobacteria with lower lesion volumes (β coefficient = −0.30 to −0.07). At the genus level, high Ruminiclostridium, whereas low Coprococcus 3 and low Erysipelatoclostridium were associated with higher lesion volumes. Interpretation Our study characterized the gut microbiota features associated with MRI lesion burden in pediatric‐onset MS, shedding light onto possible pathophysiological mechanisms.
Databáze: Directory of Open Access Journals
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