Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis

Autor: Anna-Carin Lundell, Malin Erlandsson, Maria Bokarewa, Hille Liivamägi, Karin Uibo, Sirje Tarraste, Tiina Rebane, Tiina Talvik, Chris Pruunsild, Rille Pullerits
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Immunology Research, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2018/3856897
Popis: Background. Liver-derived insulin-like growth factor-1 (IGF-1) contributes bone formation. Decreased IGF-1 levels are common in juvenile idiopathic arthritis (JIA), but whether IGF-1 is related to sex and differ during the pathogenic progress of JIA is unknown. Objective. The aim of this study was to examine IGF-1 levels in boys and girls with newly diagnosed JIA, with established JIA and in controls. Methods. The study group included 131 patients from the Estonian population-based prevalence JIA study. Blood samples were obtained from 27 boys and 38 girls with early JIA (≤1 month from the diagnosis), 29 boys and 36 girls with established JIA (mean disease duration 18 months), and from 47 age- and sex-matched controls. Results. IGF-1 levels in boys were significantly decreased in early JIA compared to male controls, while IGF-1 levels in girls were comparable between JIA and controls. In early JIA, IGF-1 levels were 12-fold lower in boys relative to girls. In controls, IGF-1 levels correlated with both age and height, while these correlations were lost in boys with early JIA. Conclusion. We report a sex-dependent deficiency in serum IGF-1 in boys with early JIA, which argues for sex-related differences in biological mechanisms involved in the disease pathogenesis.
Databáze: Directory of Open Access Journals
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