Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives

Autor: Gianluca Pellino, Gaetano Gallo, Pierlorenzo Pallante, Raffaella Capasso, Alfonso De Stefano, Isacco Maretto, Umberto Malapelle, Shengyang Qiu, Stella Nikolaou, Andrea Barina, Giuseppe Clerico, Alfonso Reginelli, Antonio Giuliani, Guido Sciaudone, Christos Kontovounisios, Luca Brunese, Mario Trompetto, Francesco Selvaggi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Gastroenterology Research and Practice, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1687-6121
1687-630X
DOI: 10.1155/2018/2397863
Popis: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies). Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA). Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients. The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC. Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation in the development of a bespoke treatment of CRC.
Databáze: Directory of Open Access Journals
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