Transcriptional response of OmpC and OmpF in Escherichia coli against differential gradient of carbapenem stress

Autor:	Shiela Chetri, Melson Singha, Deepshikha Bhowmik, Kathakali Nath, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	OmpF OmpC micF Carbapenem Escherichia coli Real time PCR Medicine Biology (General) QH301-705.5 Science (General) Q1-390
Zdroj:	BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Druh dokumentu:	article
ISSN:	1756-0500
DOI:	10.1186/s13104-019-4177-4
Popis:	Abstract Objective This study was designed to investigate the transcriptional response of OmpF and OmpC along with an antisense RNA, MicF under concentration gradient carbapenem exposure. Result An elevation in the expression of OmpF gene under concentration gradient imipenem stress from a particular concentration was observed. For OmpC gene a significant decrease in the expression was noticed under concentration gradient imipenem and meropenem stress. The study showed reduction in the expression of OmpC gene against imipenem and meropenem possibly preventing the entry of carbapenem antibiotic inside the cell indicating a possible role in carbapenem resistance.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3b62c5fbcbd649918d3260ceb4be7cb7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.