Spectrophotometric Determination of Mesalazine in Pharmaceutical Preparations by Oxidative Coupling Reactions with m-Aminophenol and 2,6- Dihydroxybenzoic Acid
| Autor: | Aziz et al. |
|---|---|
| Jazyk: | Arabic<br />English |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Baghdad Science Journal, Vol 16, Iss 4(Suppl.) (2019) |
| Druh dokumentu: | article |
| ISSN: | 2078-8665 2411-7986 |
| DOI: | 10.21123/bsj.2019.16.4(Suppl.).1010 |
| Popis: | Tow simple, rapid and sensitive spectrophotometric methods for the determination of mesalazine in pharmaceutical preparations have been carried out. The proposed methods depend on oxidative coupling reaction of mesalazine with m-aminophenol in the existence of N-bromosuccinamide in alkaline medium (method A) and 2,6-dihydroxybenzoic acid in the existence of sodium metaperiodate in basic medium (method B) to produce colored products , show highest absorptions at 640 (nm) and 515 (nm), alternately. Beer’s law was consistent in concentrations extent of 1.25-30 and 0.5-12.5 (µg.mL-1) with molar absorptivity of 0.36×104 and 0.77×104 L.mol-1.cm-1, alternately. The limits of detection (LOD) were 0.0144 and 0.0829 µg.mL-1, while limits of quantitation (LOQ) were 0.0483 and 0.2766 (µg.mL-1), alternately. The suggested methods have been applied successfully to the determination of mesalazine in its pharmaceutical preparations as tablets and suppositories. |
| Databáze: | Directory of Open Access Journals |
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