Impact of extrathyroidal autoimmune diseases on clinical features and the efficacy of Iodine‐131 therapy in patients with differentiated thyroid cancer

Autor: Ya‐hong Long, Na Li, Le Ma, Wan‐chun Zhang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.70018
Popis: Abstract Objective The aim of this study is to assess the impact of extrathyroidal autoimmune diseases (ADs) on the clinical characteristics and efficacy of iodine‐131 (131I) therapy in patients with differentiated thyroid cancer (DTC). Methods Patients with DTC who were received 131I therapy simultaneously were classified into the combination group (n = 35) and noncombination group (n = 146) depending on the presence of ADs. The clinical characteristics, such as gender, age, tumor lesions, lymph node metastasis, distant metastasis, 131I therapy efficacy, and use of levothyroxine, were compared between the two groups. Statistical analysis was conducted using SPSS 26.0 and R 4.0.3. Results There was a statistically significant difference in age between the combination and noncombination groups (t = −2.872, p .05), and there was no significant difference in the therapeutic efficacy of 131I between the two groups (p > .05). In the subgroup analysis involving patients aged great than 50.5 years, the levothyroxine/weight (µg/kg) was increased in the combination group, and the difference was statistically significant (p
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