Effect of Citrullus lanatus Seeds Extract on Haematological Parameters After Administration with Medroxyprogesterone Acetate on Female Wistar Rats
| Autor: | Michael Chuks Nnumolu, Onyeso Godspower |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Biology, Medicine & Natural Product Chemistry, Vol 12, Iss 2, Pp 611-617 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2089-6514 2540-9328 |
| DOI: | 10.14421/biomedich.2023.122.611-617 |
| Popis: | This study was carried out to investigate the effect of Citrullus lanatus seeds extract on the haematological parameters after administration with medroxyprogesterone acetate on female Wistar rats. Twenty-five rats weighing 170-230 g were divided into five groups containing five rats each. Group I served as control and received only rat chow and water; Group II received rat chow, water and a high dose of MPA only; Group III received rat chow, water, a high dose of MPA and a high dose of extract; group IV received rat chow, water, high dose of MPA and a low dose of extract, and group V received rat chow, water and high dose of extract only. The administration lasted for twenty-eight days after two weeks of acclimatisation. On the twenty-ninth day, the animals were anaesthetised using chloroform, sacrificed and their blood samples obtained via cardiac puncture for haematology analysis. The results showed that the level of haematological parameters significantly increased (p |
| Databáze: | Directory of Open Access Journals |
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