Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation

Autor: Vera Lúcia Portal, Emílio H. Moriguchi, José Luiz da Costa Vieira, Sadi Schio, Eduardo T. Mastalir, Fabiana Buffé, Eleni Borges Bortolini, Ricardo Santalucia Brüch, Rubem Rodrigues
Jazyk: English<br />Portuguese
Rok vydání: 2003
Předmět:
Zdroj: Arquivos Brasileiros de Cardiologia, Vol 80, Iss 2, Pp 156-161 (2003)
Druh dokumentu: article
ISSN: 0066-782X
1678-4170
DOI: 10.1590/S0066-782X2003000200004
Popis: OBJECTIVE: To study the differences between fluvastatin and pravastatin regarding LDL susceptibility to oxidation, plasma levels of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG) in hypercholesterolemic patients with established coronary heart disease (CHD). METHODS: A double-blind randomized parallel study was conducted that included 41 hypercholesterolemic outpatients with CHD treated at the Instituto de Cardiologia do Rio Grande do Sul. The inclusion criteria were LDL-C above 100 mg/dL and triglycerides below 400 mg/dL based on 2 measures. After 4 weeks on a low cholesterol diet, those patients that fullfilled the inclusion criteria were randomized into 2 groups: the fluvastatin group (fluvastatin 40 mg/day) and the pravastatin group (pravastatin 20 mg/day), for 24 weeks of treatment. LDL susceptibility to oxidation was analyzed with copper-induced production of conjugated dienes (Cu2+) and water-soluble free radical initiator azo-bis (2'-2'amidinopropanil) HCl (AAPH). Spectroscopy nuclear magnetic resonance was used for determination of lipids. RESULTS: After 24 weeks of drug therapy, fluvastatin and pravastatin significantly reduced LDL susceptibility to oxidation as demonstrated by the reduced rate of oxidation (azo and Cu) and by prolonged azo-induced lag time (azo lag). The TC, LDL-C, and TG reduced significantly and HDL-C increased significantly. No differences between the drugs were observed. CONCLUSION: In hypercholesterolemic patients with CHD, both fluvastatin and pravastatin reduced LDL susceptibility to oxidation.
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