| Autor: |
Wei Zhang, Guo-Sheng Li, Xiang-Yu Gan, Zhi-Guang Huang, Rong-Quan He, Hong Huang, Dong-Ming Li, Yu-Lu Tang, Deng Tang, Wen Zou, Jun Liu, Yi-Wu Dang, Gang Chen, Hua-Fu Zhou, Jin-Liang Kong, Hui-ping Lu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
PeerJ, Vol 11, p e15598 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2167-8359 |
| DOI: |
10.7717/peerj.15598 |
| Popis: |
Background Worldwide, lung squamous cell carcinoma (LUSC) has wreaked havoc on humanity. Matrix metallopeptidase 12 (MMP12) plays an essential role in a variety of cancers. This study aimed to reveal the expression, clinical significance, and potential molecular mechanisms of MMP12 in LUSC. Methods There were 2,738 messenger RNA (mRNA) samples from several multicenter databases used to detect MMP12 expression in LUSC, and 125 tissue samples were validated by immunohistochemistry (IHC) experiments. Receiver operator characteristic (ROC) curves, Kaplan–Meier curves, and univariate and multivariate Cox regression analyses were used to assess the clinical value of MMP12 in LUSC. The potential molecular mechanisms of MMP12 were explored by gene enrichment analysis and immune correlation analysis. Furthermore, single-cell sequencing was used to determine the distribution of MMP12 in multiple tumor microenvironment cells. Results MMP12 was significantly overexpressed at the mRNA level (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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