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Yanwei Zhao,1 Gang Wu,2 Haiming Shi,3,4 Zhijie Xia,1 Tao Sun3,4 1Emergency Department, Huashan Hospital North, Fudan University, Shanghai, People’s Republic of China; 2Emergency Department, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 3Cardiology Division, Huashan Hospital North, 4Cardiology Division, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Background: The purpose of this study was to determine a new method for the early diagnosis and assessment of mild cognitive impairment in elderly individuals with hypertension. Elderly hypertensive patients with cognitive impairment were assessed by the Montreal Cognitive Assessment (MoCA) and Clinical Dementia Rating Assessment (CDR). Cognitive results were compared to apparent diffusion coefficient (ADC) values from magnetic resonance-diffusion weighted imaging. Methods: A total of 191 patients were categorized into four groups: a control group (normal cognition and no hypertension; n=20); a normal group (hypertension and normal cognition; n=33); an mild cognitive impairment group (n=80); and a vascular dementia group (n=58). The MoCA and CDR tests were used to determine cognition. ADC values in eight brain regions were calculated with magnetic resonance-diffusion weighted imaging. Other characteristics were evaluated, eg, blood pressure, MoCA, and CDR scores, and the comparisons of the four groups were made. Results: The MoCA and CDR scores differed among the four groups (P |
