Comparative Study of Branched Chain Amino Acids Infusion with Conventional treatment in patients with Hepatic Encephalopathy due to Liver Cirrhosis
| Autor: | Mohammad Abdur Rahman Afridi, Aftab Ahmad, Zafar Ali, Javed Iqbal Farooqi, Riaz Mohammad, Intekhab Alam |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Khyber Medical University Journal, Vol 6, Iss 4, Pp 163-166 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2305-2643 2305-2651 |
| Popis: | OBJECTIVE: To determine the effectiveness of branched chain amino acid (BCAA) infusion with conventional therapy in the treatment of hepatic encephalopathy (HE) due to liver cirrhosis. METHODOLOGY: This was a hospital based randomized controlled trial, conducted in the department of medicine, Lady Reading Hospital, Peshawar from February 2012 to July 2012. A total number of 86 patients, of either gender, presenting with grade II, III and IV HE due to cirrhosis were included in the study. They were randomly allocated into two groups by lottery method. Forty three patients in group A were subjected to conventional treatment plus infusion of BCAA (Aminoleban, Otsuka); while 43 patients in group B were subjected to conventional treatment only, which consisted of antibiotics and lactulose. Data analysis was performed using SPSS version 20. ‘Chi square’ test was used to compare the effectiveness in both groups with p value of < 0.05 as significant. RESULTS: Out of 86 patients included in the study, 52(60.5%) were males and 34 (39.5%) were females. Mean age of the sample was 49.73±7.958 years with age range from 35 to 70 years. After the administration of BCAA infusion twice daily for 3 days, clinical improvement was observed in 33 (76.7%) patients in group A while in group B only 10 (23.3%) patients improved clinically, showing p-value |
| Databáze: | Directory of Open Access Journals |
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