Naturally Acquired Antibodies against Haemophilus influenzae Type a in Aboriginal Adults, Canada

Autor: Eli B. Nix, Kylie Williams, Andrew D. Cox, Frank St. Michael, Sandra Romero-Steiner, Daniel S. Schmidt, William G. McCready, Marina Ulanova
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 21, Iss 2, Pp 273-279 (2015)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2102.140722
Popis: In the post-Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunocompromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure.
Databáze: Directory of Open Access Journals
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