Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss

Autor: Nadia Benedetto, Claudia Mangieri, Filomena De Biasio, Ricardo Filipe Carvalho, Luigi Milella, Daniela Russo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: FEBS Open Bio, Vol 14, Iss 6, Pp 955-967 (2024)
Druh dokumentu: article
ISSN: 2211-5463
00432199
DOI: 10.1002/2211-5463.13805
Popis: Patterned hair loss (PHL) or androgenetic alopecia is a condition affecting about 50% of people worldwide. Several pharmacological medications have been developed over the years, but few studies have investigated their effectiveness. Therefore, new, safer and more effective strategies are required. Recent investigations showed that Annurca apple extract application could induce keratin production and promote hair growth thanks to the high amount of procyanidin B2 contained in. Hence, this study aimed to investigate the role of an Annurca apple extract in preventing PHL by testing it on human follicle dermal papilla cells (HFDPCs) for the first time. Treatment of HFDPCs with Annurca apple extract counteracted intracellular reactive oxygen species accumulation by increasing the activity of antioxidant enzymes such as superoxide dismutase 2 and catalase. Furthermore, treatment with Annurca apple extract increased β‐catenin and fibroblast growth factor 2, which are involved in hair growth stimulation. These data suggest that Annurca apple extract may be a potential therapeutically useful nutraceutical product for preventing or treating hair loss by reducing oxidative stress and inducing the expression of hair growth‐related factors.
Databáze: Directory of Open Access Journals
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