| Autor: |
Bandar Alghanem, Fatmah A. Mansour, Hayat Shaibah, Khawlah Almuhalhil, Feras Almourfi, Hassan S. Alamri, Hala Alajmi, Mamoon Rashid, Fayhan Alroqi, Maroua Jalouli, Abdel Halim Harrath, Mohammad Boudjellal, Tlili Barhoumi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 9, Iss 4, Pp e15224- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2023.e15224 |
| Popis: |
Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis of plasma samples from mild, moderate and severe COVID-19 patients. Analysis revealed differentially expressed proteins and different therapeutic potential targets related to innate immune responses such as fetuin-A, tetranectin (TN) and paraoxonase-1 (PON1). Furthermore, protein changes in plasma showed dysregulation of complement and coagulation cascades in COVID-19 patients compared to healthy controls. In conclusion, our proteomics data suggested fetuin-A and TN as potential targets that might be used for diagnosis as well as signatures for a better understanding of the pathogenesis of COVID-19 disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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