Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

Autor: Thalita Vieira Nascimento Ximenes, Raquel Carvalho, Iluska Senna Bonfá, Vanessa Samúdio Santos, Luciane Candeloro, Flávio Macedo Alves, Denise Brentan Silva, Carlos Alexandre Carollo, Karine de Cássia Freitas Gielow, Saulo Euclides Silva-Filho, Mônica Cristina Toffoli-Kadri
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pharmaceuticals, Vol 15, Iss 10, p 1258 (2022)
Druh dokumentu: article
ISSN: 15101258
1424-8247
DOI: 10.3390/ph15101258
Popis: The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.
Databáze: Directory of Open Access Journals
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