Association between circulatory complement activation and hypertensive renal damage: a case–control study

Autor:	Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Complement system hypertensive renal damage complement C3 alternative complement pathway (AP) CFH Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Renal Failure, Vol 46, Iss 2 (2024)
Druh dokumentu:	article
ISSN:	0886022X 1525-6049 0886-022X
DOI:	10.1080/0886022X.2024.2365396
Popis:	Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.Results Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3ae8cd875aaa4a5793f5b4afb573a1ab Zobrazit plný text záznamu View record in DOAJ