Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
| Autor: | SERGIO E RECABARREN, ALEJANDRO LOBOS, YARA FIGUEROA, VASANTHA PADMANABHAN, DOUGLAS L FOSTER, TERESA SIR-PETERMANN |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Biological Research, Vol 40, Iss 3, Pp 329-338 (2007) |
| Druh dokumentu: | article |
| ISSN: | 0716-9760 0717-6287 |
| Popis: | Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg), as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the response curve (AUC) of LH increased progressively in both controls and prenatal T-treated males from 5 to 20 weeks of age (P |
| Databáze: | Directory of Open Access Journals |
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