CX3 chemokine receptor 1 defciency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus
| Autor: | Feng Xiao, Jun-mei Xu, Xing-hua Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
active zone stability
Drosophila neuromuscular junction dephosphorylation Liprin-α Syd-1 PP2A GSK-3ß living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration injury plasticity neurodegenerative disease brain therapy neuron microglia neural progenitor tissue engineering neuroregeneration repair central nervous system biomaterial regenerative medicine nanotechnology spinal cord injury axonal regeneration exosome extracellular vesicle microRNA microvesicle nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises nerve regeneration hypoxic-ischemic brain damage ginsenoside Rg1 neural stem cells cell transplantation cell differentiation cognition nerve reconstruction neural regeneration brain injury neuroimaging functional magnetic resonance imaging regional homogeneity apoplexy subacute ischemia participants healthy volunteers brain activity NSFC grants neuroprotection cerebral ischemia/reperfusion injury lateral intracerebroventricular injection Apelin-13 nerve apoptosis Bcl-2 caspase-3 fractalkine CX3 chemokine receptor 1 neuronal maturation dendrites doublecortin synaptic maturation newborn neurons Neurology. Diseases of the nervous system RC346-429 |
| Zdroj: | Neural Regeneration Research, Vol 10, Iss 5, Pp 772-777 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.156979 |
| Popis: | Previous studies have shown that microglia impact the proliferation and differentiation of neurons during hippocampal neurogenesis via the fractalkine/CX3 chemokine receptor 1 (CX3CR1) signaling pathway. However, whether microglia can influence the maturation and dendritic growth of newborn neurons during hippocampal neurogenesis remains unclear. In the present study, we found that the number of doublecortin-positive cells in the hippocampus was decreased, and the dendritic length and number of intersections in newborn neurons in the hippocampus were reduced in transgenic adult mice with CX3CR1 deficiency (CX3CR1GFP/GFP). Furthermore, after experimental seizures were induced with kainic acid in these CX3CR1-deficient mice, the expression of c-fos, a marker of neuronal activity, was reduced compared with wild-type mice. Collectively, the experimental findings indicate that the functional maturation of newborn neurons during hippocampal neurogenesis in adult mice is delayed by CX3CR1 deficiency. |
| Databáze: | Directory of Open Access Journals |
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