| Autor: |
Qiang Li, XiaoXiao Liu, Mengxiao Jia, Fang Sun, Yingsha Li, Hexuan Zhang, Xiaoli Liu, Hongbo He, Zhigang Zhao, Zhencheng Yan, Zhiming Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-8 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1758-5996 |
| DOI: |
10.1186/s13098-022-00864-3 |
| Popis: |
Abstract Objective To investigate the potential of employing sublingual microcirculation as an early noninvasive screening technique for diabetic nephropathy (DN). Research design and methods We recruited 89 patients with type 2 diabetes mellitus (T2DM) and 41 healthy subjects in this cross-sectional observational study. All participants underwent fluorescein fundus angiography, vibration perception testing, 10 g (Semmes–Weinstein) monofilament examination, nerve conduction velocity, and 24-h urine microalbumin determination. HbA1c, fasting plasma glucose, blood lipid, and estimated glomerular filtration rate(eGFR) were measured. Sublingual microcirculatory images were captured using side-stream dark-field (SDF) microcirculation microscopy, and total and perfused vascular density (TVD and PVD) were calculated. Results The sublingual microcirculatory parameters denoting microvascular density and perfusion were negatively correlated with both fasting plasma glucose (TVD, r = − 0.316, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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