Direct antiglobulin test in the differential diagnosis of ABO hemolytic disease of the newborn: an important tool with high negative predictive value

Autor: Samira Ali Abbas, Carla Luana Dinardo, Cárlei Heckert Godinho, Karen Ziza, Bruno Cruz, Juliana Oliveira Martins, Elyse Moritz, Dante M. Langui, José O. Bordin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Hematology, Transfusion and Cell Therapy, Vol 46, Iss 4, Pp 450-454 (2024)
Druh dokumentu: article
ISSN: 2531-1379
DOI: 10.1016/j.htct.2024.03.001
Popis: Background: Hemolysis due to ABO incompatibility is an important differential diagnosis in newborns presenting with jaundice. Clinical studies evaluating ABO hemolytic disease of fetus and newborn (ABO-HDFN) question the diagnostic value of the direct antiglobulin test (DAT) in this situation. Goals: To determine the clinical and laboratorial findings associated with the occurrence of ABO-HDFN and to evaluate the accuracy of DAT as a diagnostic tool. Methods: This was a nested case control study with a cohort of 4122 newborns. Clinical and immunohematological data were retrieved from medical files including clinical and laboratorial factors associated with ABO-HDFN. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of positive DAT were calculated. Results: Among the 4122 newborns, 44 had the diagnosis of ABO-HDFN. Positive DAT, group O mother and group A newborn were significantly associated with the occurrence of neonatal jaundice and this association persisted in a multivariable model (p-value
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