Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
| Autor: | Rosalie A. Poldervaart, Mirjam Laging, Tessa Royaards, Judith A. Kal-van Gestel, Madelon van Agteren, Marry de Klerk, Willij Zuidema, Michiel G. H. Betjes, Joke I. Roodnat |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Transplantation, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2090-0007 2090-0015 |
| DOI: | 10.1155/2015/748102 |
| Popis: | Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been performed. In conventional and ABO-incompatible transplantation the willing donor becomes an actual donor for the intended recipient. In kidney-exchange and domino-donation the donor donates indirectly to the intended recipient. The relationship between the donor and intended recipient was studied. There were 935 conventional and 297 alternative program transplantations. There were 66 ABO-incompatible, 68 domino-paired, 62 kidney-exchange, and 104 altruistic donor transplantations. Waiting list recipients (n=101) were excluded as they did not bring a living donor. 1131 couples remained of whom 196 participated in alternative programs. Genetically unrelated donors (486) were primarily partners. Genetically related donors (645) were siblings, parents, children, and others. Compared to genetically related couples, almost three times as many genetically unrelated couples were incompatible and participated in alternative programs (P |
| Databáze: | Directory of Open Access Journals |
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