Nonalcoholic fatty liver disease burden – Saudi Arabia and United Arab Emirates, 2017–2030
| Autor: | Khalid Alswat, Abdulrahman A Aljumah, Faisal M Sanai, Faisal Abaalkhail, Mohamed Alghamdi, Waleed K Al Hamoudi, Abdullah Al Khathlan, Huda Al Quraishi, Ahmed Al Rifai, Mohamed Al Zaabi, Mohamed A Babatin, Chris Estes, Almoutaz Hashim, Homie Razavi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Burden of disease
cardiovascular disease cirrhosis decompensated cirrhosis healthcare resource utilization hepatocellular carcinoma metabolic syndrome nonalcoholic fatty liver nonalcoholic fatty liver disease nonalcoholic steatohepatitis obesity type 2 diabetes mellitus Diseases of the digestive system. Gastroenterology RC799-869 |
| Zdroj: | The Saudi Journal of Gastroenterology, Vol 24, Iss 4, Pp 211-219 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1319-3767 1998-4049 |
| DOI: | 10.4103/sjg.SJG_122_18 |
| Popis: | Background/Aim: Due to epidemic levels of obesity and type 2 diabetes mellitus (DM), nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) will be driving factors in liver disease burden in the coming years in Saudi Arabia and United Arab Emirates (UAE). Materials and Methods: Models were used to estimate NAFLD and NASH disease progression, primarily based on changes in adult prevalence rates of adult obesity and DM. The published estimates and expert interviews were used to build and validate the model projections. Results: In both countries, the prevalence of NAFLD increased through 2030 parallel to projected increases in the prevalence of obesity and DM. By 2030, there were an estimated 12,534,000 NAFLD cases in Saudi Arabia and 372,000 cases in UAE. Increases in NASH cases were relatively greater than the NAFLD cases due to aging of the population and disease progression. Likewise, prevalent cases of compensated cirrhosis and advanced liver disease are projected to at least double by 2030, while annual incident liver deaths increase in both countries to 4800 deaths in Saudi Arabia and 140 deaths in UAE. Conclusions: Continued high rates of adult obesity and DM, in combination with aging populations, suggest that advanced liver disease and mortality attributable to NAFLD/NASH will increase across both countries. Reducing the growth of the NAFLD population, along with potential therapeutic options, will be needed to reduce liver disease burden. |
| Databáze: | Directory of Open Access Journals |
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