| Autor: |
Doron Yablecovitch, Moshe Nadler, Shomron Ben‐Horin, Orit Picard, Miri Yavzori, Ella Fudim, Moran Tardio Duchan, Emad Sakhnini, Alon Lang, Maor Lahav, Talia Saker, Sandra Neuman, Limor Selinger, Biana Freitz, Revital Dvir, Maria Raitses‐Gurevich, Talia Golan, Idan Levy, Ido Laish |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Cancer Medicine, Vol 13, Iss 17, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.70144 |
| Popis: |
Abstract Aims and Background Matrix metalloproteinase‐7 (MMP‐7) and Syndecan‐1 (SDC1) are involved in multiple functions during tumorigenesis. We aimed to evaluate the diagnostic and prognostic performance of these serum proteins, as potential biomarkers, in patients with pancreatic ductal adenocarcinoma (PDAC) and benign pancreatic cysts. Methods In this case–control study, patients with newly diagnosed PDAC (N = 121) were compared with the benign cyst (N = 66) and healthy control (N = 48) groups. Serum MMP‐7 and SDC1 were measured by ELISA. The diagnostic accuracy of their levels for diagnosing PDAC and pancreatic cysts was computed, and their association with survival outcomes was evaluated. Results MMP‐7 median serum levels were significantly elevated in the PDAC (7.3 ng/mL) and cyst groups (3.7 ng/mL) compared with controls (2.9 ng/mL) (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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