| Autor: |
Heather A. Boger, Lawrence D. Middaugh, Ann-Charlotte Granholm, Jacqueline F. McGinty |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Neurobiology of Disease, Vol 33, Iss 3, Pp 459-466 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1095-953X |
| DOI: |
10.1016/j.nbd.2008.11.013 |
| Popis: |
Inflammation, phospho-p38 MAPK activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson's disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month-old GDNF heterozygous (GDNF+/−) mice were previously reported and both were exacerbated by a toxic methamphetamine binge. The current study assessed the effects of minocycline on these methamphetamine-induced effects. Minocycline (45 mg/kg, i.p.×14 days post-methamphetamine or saline injections) reduced microglial activation and phospho-p38 MAPK in the substantia nigra of saline-treated GDNF+/− mice and in methamphetamine-treated wildtype and GDNF+/− mice. Although minocycline increased tyrosine hydroxylase-immunoreactivity in GDNF+/− mice, it did not attenuate the methamphetamine-induced reduction of tyrosine hydroxylase. The results suggest that neuroinflammation is deleterious to the dopamine system of GDNF+/− mice but is not the primary cause of methamphetamine-induced damage to the dopamine system in either GDNF+/− or wildtype mice. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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