Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction

Autor:	Pietro Capurro, Lisa Moni, Andrea Galatini, Christian Mang, Andrea Basso
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	multicomponent reactions Ugi-azide chiral imines tetrazoles diversity-oriented synthesis Organic chemistry QD241-441
Zdroj:	Molecules, Vol 23, Iss 11, p 2758 (2018)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules23112758
Popis:	Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target product through an Ugi-azide three-component reaction (UA-3CR). The final products are equipped with additional functionalities which can be further elaborated for the generation of combinatorial libraries of enantiopure heterocycles.
Databáze:	Directory of Open Access Journals
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