Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis
| Autor: | Wen-Hsuan Yang, Jen-Tsan Chi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
ferroptosis
hippo pathway transcriptional coactivator with pdz-binding motif (taz) yes-associated protein 1 (yap1) nadph oxidase 4 (nox4) renal cell carcinoma ovarian cancer erastin epithelial membrane protein 1 (emp1) angiopoietin-like 4 (angptl4) nadph oxidase 2 (nox2) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| Zdroj: | Molecular & Cellular Oncology, Vol 7, Iss 1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 |
| DOI: | 10.1080/23723556.2019.1699375 |
| Popis: | Ferroptosis is a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors. |
| Databáze: | Directory of Open Access Journals |
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