| Autor: |
Jacob Kehinde Akintunde, Olakunle Enock Bolarin |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Acute Disease, Vol 4, Iss 4, Pp 298-304 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2221-6189 |
| DOI: |
10.1016/j.joad.2015.06.008 |
| Popis: |
Objectives: To evaluate the toxicity of lisinopril in liver of male rats and its reversal effect of garlic capsule (GAR) and selenium-vitamin A, vitamin B, vitamin C (SACE). Methods: Thirty five adult male wistar rats were randomly assigned into 5 groups of 7 animals per group. Group I serves as the control, animals in Groups II, III, IV and V received 28 mg/kg body weight of lisinopril via oral route. Group III was co-treated with GAR at therapeutic dose of 250 mg/kg body weight per day. Group IV was co-treated with SACE at dose of 500 mg/kg body weight. Lastly, group V was co-treated with GAR and SACE at doses of 250 and 500 mg/kg body weight respectively, and the experiment last for 8 days. Results: Administration of lisinopril caused systemic toxicity in liver as well as adverse histopathologic changes in the tested tissue. While GAR and SACE significantly (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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