Renal function estimation formulas in predicting long-term cardiovascular outcomes in patients with myocardial infarction concurrent with diabetes mellitus

Autor: V N Karetnikova, A V Osokina, M V Evseeva, V V Kalaeva, O V Gruzdeva, V V Kashtalap, M V Zykov, O E Avramenko, O L Barbarash
Jazyk: ruština
Rok vydání: 2016
Předmět:
Zdroj: Терапевтический архив, Vol 88, Iss 4, Pp 35-40 (2016)
Druh dokumentu: article
ISSN: 0040-3660
2309-5342
Popis: Aim. To comparatively assess formulas for estimating glomerular filtration rate (GFR) in the prediction of poor outcomes in patients with type 2 diabetes mellitus (DM) within one year after myocardial infarction (MI). Subjects and methods. The investigators examined 89 patients with ST-segment elevation myocardial infarction (STEMI) within 24 hours after the onset of clinical symptoms of the disease. All the patients underwent standard laboratory and instrumental tests. GFR was calculated using the Modified of Diet in Renal Diseases (MDRD) formulas in terms of serum creatinine levels, the Hoek equation: GFR [ml/min/1.73 m2] = (80.35/cystatin C [mg/l]) — 4.3 (CKD-EPI), as well as from cystatin C levels, and the creatinine clearance rate was determined using the Cockcroft and Gault formula (ml/min). During a year after STEMI, the investigators recorded cardiovascular events (CVEs), such as death, recurrent MI, progressive angina pectoris, emergency coronary revascularization, and decompensated chronic heart failure (CHF). The examinees were divided into two groups: 1) 70 (78.6%) patients with MI and no DM; 2) 19 (21.3%) patients with MI and DM. Results. Comparative analysis revealed a tendency towards a difference in the detection rate of GFR
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