| Autor: |
Gulcin Tezcan, Fatma Ozdemir, Gulsah Cecener, Secil Ak Aksoy, Berrin Tunca, Erol Armagan, Ozlem Koksal, Pinar Cinar Sert |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Van Tıp Dergisi, Vol 26, Iss 2, Pp 167-176 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2587-0351 |
| DOI: |
10.5505/vtd.2019.02359 |
| Popis: |
INTRODUCTION: miR-1 miR-133a and miR-133b release into the circulation during the early stages of acute coronary syndrome (ACS). However, their discriminative expression pattern in ST-elevation myocardial infarction (STEMI) and Non-ST-elevation myocardial infarction (NSTEMI) remains unknown. The aim of the present study was to characterize and compare the circulating miR-1, miR-133a and miR-133b expression levels in peripheral blood samples of ACS patients to determine their discriminative expression pattern of STEMI or NSTEMI. METHODS: Peripheral blood samples were taken from 54 patients with ACS (27 STEMI, 27 NSTEMI) and 20 healthy volunteers. The expression levels of miR-1, miR-133a and miR-133b were measured by qRT-PCR. The association of miRNA expressions and characteristics of STEMI and NSTEMI patients were evaluated using a web-based program 'RT2 Profiler PCR Array Data Analysis'. RESULTS: The expression levels of miR-1, miR-133a and miR-133b were higher in ACS than the control group (P< 0.05). However, the expression pattern of miRNAs differs between STEMI and NSTEMI patients, time-dependently. While miRNA expressions were in positive correlation with CK-MB in STEMI, they were in negative correlation in NSTEMI patients. DISCUSSION AND CONCLUSION: Our findings suggest that the dynamic expression of miR-1, miR-133a and miR-133b could predict the severity and progression of coronary heart disease in ACS patients. Advanced functional studies and larger cohort validations are required. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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