Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis

Autor: Gilda Portalatin, Shruti Shettigar, Astrid Carrion-Rodriguez, Sushma Medikayala, Leal Herlitz, Dianne Sandy, Surafel K. Gebreselassie, Shane A. Bobart
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Case Reports in Nephrology and Dialysis, Vol 12, Iss 3, Pp 219-225 (2022)
Druh dokumentu: article
ISSN: 2296-9705
00052639
DOI: 10.1159/000526391
Popis: Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing over-the-counter diet shakes containing the herbal supplement Uncaria tomentosa who developed acute kidney injury with a serum creatinine of 3.6 mg/dL up from a baseline of 0.7 mg/dL. Serological evaluation was negative, and kidney biopsy revealed interstitial inflammatory infiltrates including focally prominent eosinophils and multifocal tubulitis. Stopping the keto-diet shake containing Uncaria tomentosa and concomitant corticosteroid therapy resulted in improvement in kidney function to near baseline. To our knowledge, this is the only biopsy-proven case of AIN in the setting of Uncaria tomentosa use.
Databáze: Directory of Open Access Journals
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