ASSOCIATION BETWEEN BLOOD 25-(OH)D3 LEVEL AND ACUTE INFECTIOUS DISEASES IN CHILDREN

Autor: ZHANG Zhe, PAN Hua, LYU Zhenmei, LI Li, YI Mingji, SONG Aiqin
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: 精准医学杂志, Vol 38, Iss 1, Pp 18-21 (2023)
Druh dokumentu: article
ISSN: 2096-529X
DOI: 10.13362/j.jpmed.202301005
Popis: Objective To investigate the association between blood 25-hydroxyvitamin D3 [25-(OH)D3] level and acute infectious diseases in children. Methods A total of 114 children with acute infectious diseases who were admitted to our hospital from October 2021 to May 2022 were enrolled, and according to the severity of infection, they were divided into common infection group with 71 children and sepsis group with 43 children. At the same time, 71 children with non-infectious diseases who were admitted to Department of Pediatric Surgery in our hospital during the same period of time were enrolled as control group. According to age, each group was further divided into infancy (0.05). In the common infection group and the control group, preschool and school-aged children had a significantly lower serum level of 25-(OH)D3 than the children in infancy and early childhood (P0.05). In the sepsis group, there was no significant difference in serum 25-(OH)D3 level between different age groups (P>0.05). Comparison of children with different ages showed that the sepsis group had a significantly lower serum level of 25-(OH)D3 than the common infection group and the control group (F=7.150-58.410,P0.05). Conclusion There is no significant correlation between serum 25-(OH)D3 level and age in children with sepsis. For children with acute infectious diseases, the incidence rate of sepsis tends to increase with the reduction in the serum level of 25-(OH)D3, and therefore, 25-(OH)D3 intervention should be performed for children with acute infectious disease as soon as possible.
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