Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent
| Autor: | Zahid Ali Zounr, Ayaz Ali Memon, Abdul Ghani Memon, F. M. A. Rind, M. Y. Khuhawar, Ghulam Quadir Khaskheli, Mazhar Iqbal Khaskheli, Nazir Ahmed Brohi, Saeed Akhtar Abro |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Pakistan Journal of Analytical & Environmental Chemistry, Vol 22, Iss 01, Pp 115-126 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1996-918X 2221-5255 |
| DOI: | 10.21743/pjaec/2021.06.12 |
| Popis: | An easy, sensitive and accurate spectrophotometric method has been developed for the determination of Lisinopril (LNP) in pure and tablet formulations based on derivatization reaction with 2-hydroxynaphthaldehyde (2HNA). The derivatization reaction was carried out in methanol solvent at pH-5.5 at 95±2C for 15 min. The linear calibration curve was obtained that obeyed the Beer’s law within the concentration range 5-50 µgmL-1 of LNP at 433 nm with a coefficient of determination R²=0.996. The recovery was in the range from 98.25-101.82 with molar absorptivity of drug 9×103 mole-1cm-1. The method was accurate and precise (intra-day variation 0.05-0.97% and inter-day 0.07-1.6%), with limit of detection (LOD) and limit of quantification (LOQ) 0.264 µgmL-1 and 0.8 µgmL-1, respectively. No interferences from the excipients were detected. The method was applied for the rapid analysis of LNP in pharmaceutical products. |
| Databáze: | Directory of Open Access Journals |
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