Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies

Autor: Subramaniam Rajesh Bharathi Devi, Karunakaran Coral, Karthikeyan Gayathree, Muthuvel Bharathselvi, Shanmuganathan Sivasankar, Jyotirmoy Biswas, Pukhraj Rishi, Sundaram Natarajan, Sengamedu Srinivasa Badrinath, Narayanasamy Angayarkanni
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Indian Journal of Ophthalmology, Vol 67, Iss 10, Pp 1762-1765 (2019)
Druh dokumentu: article
ISSN: 0301-4738
1998-3689
DOI: 10.4103/ijo.IJO_400_19
Popis: We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.
Databáze: Directory of Open Access Journals
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