| Autor: |
Lin Li, Yusuke Matsui, Mary K. Prahl, Arianna G. Cassidy, Yarden Golan, Unurzul Jigmeddagva, Nida Ozarslan, Christine Y. Lin, Sirirak Buarpung, Veronica J. Gonzalez, Megan A. Chidboy, Emilia Basilio, Kara L. Lynch, Dongli Song, Priya Jegatheesan, Daljeet S. Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Taha Y. Taha, Mauricio Montano, Melanie Ott, Warner C. Greene, Stephanie L. Gaw |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2059-0105 |
| DOI: |
10.1038/s41541-024-00948-3 |
| Popis: |
Abstract Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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