Hepatic expression responses of DNA methyltransferases, heat shock proteins, antioxidant enzymes, and NADPH 4 to early life thermal conditioning in broiler chickens

Autor: Mahmoud Madkour, Mohamad M. Aboelenin, Osama Aboelazab, Ahmed A. Elolimy, Nafisa Abd El-Azeem, Mohamed S. El-Kholy, Mahmoud Alagawany, Mohamed Shourrap
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Italian Journal of Animal Science, Vol 20, Iss 1, Pp 433-446 (2021)
Druh dokumentu: article
ISSN: 1594-4077
1828-051X
1828051X
DOI: 10.1080/1828051X.2021.1890645
Popis: Early-life thermal conditioning (TC) in broiler chickens has long-lasting impacts on later life. Therefore, this study aimed to clarify the molecular mechanism by which TC impacts the hepatic expression heat shock proteins (hsps), antioxidant enzymes, NADPH oxidase 4 (NOX4), glucocorticoid receptor (GR), and DNA methyltransferases genes in broiler chicks at five weeks of age. Two hundred forty one-day-old male broiler chicks of Cobb 500 were allocated into four equal experimental groups. The first group was under the optimal brooding conditions (control), whereas the 2nd, 3rd, and 4th groups were exposed to TC at 39 ± 1 °C for six hours on the third-, fifth- or seventh-day post-hatch, respectively. At 35 days of age, all chicks of four experimental groups were subjected to heat challenge by exposure to 36 ± 1 °C for six hours. Results showed that broilers exposed to TC on the fifth-day post-hatch when exposed to acute heat stress at five weeks of age had the lowest plasma CORT level, the lowest expression (p
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