| Autor: |
Kai-Bo Wang, Yushuang Liu, Jinzhu Li, Chengmei Xiao, Yingying Wang, Wei Gu, Yipu Li, Yuan-Zheng Xia, Tingdong Yan, Ming-Hua Yang, Ling-Yi Kong |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-33761-4 |
| Popis: |
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules. The study provides molecular details of ligand interactions with KRAS-G4 and contributes insight into the design of specific KRAS-G4-interactive drugs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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