Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain

Autor: Yanyan Zhang, Dan Yi, Haiwang Xu, Zihan Tan, Yuxuan Meng, Tao Wu, Lei Wang, Di Zhao, Yongqing Hou
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Veterinary Research, Vol 18, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1746-6148
DOI: 10.1186/s12917-022-03410-5
Popis: Abstract Background The purpose of this research is to determine the effects of sodium gluconate (SG) on the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain expressing heat-stable type I toxin (STa). Results Pigs (n = 24, 21 days of age) were randomly allocated to three treatments: Control group (pigs were fed basal diet), STa group (pigs were fed basal diet and challenged with a recombinant E. coli strain expressing STa), and SG group (pigs were fed basal diet supplemented with 2500 mg/kg sodium gluconate and challenged with a recombinant E. coli strain expressing STa). The trial period lasted for 15 days. On days 12 and 13, pigs in the STa and SG groups were orally administered with the recombinant Escherichia coli strain, while those in the control group were orally administered with normal saline at the same volume. On day 15, blood, intestinal tissues and colonic contents were collected for further analysis. Results showed that dietary SG supplementation had a tendency to increase average daily gain, and reduced (P
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