| Autor: |
Xingliang Dai, Junjuan Fan, Dongdong Liu, Huaixu Li, Lei Shu, Peng Gao, Senhua Chen, Xianwen Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Smart Materials in Medicine, Vol 5, Iss 1, Pp 66-74 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1834 |
| DOI: |
10.1016/j.smaim.2023.08.001 |
| Popis: |
Glioma is the most common malignant tumor of the central nervous system. Drug-assisted chemotherapy is an important adjuvant treatment post-surgery, but currently, effective chemotherapy drugs for glioma are lacking. Expediting new and effective chemotherapy drugs is a persistent problem that needs to be solved. In this study, a tetramic acid derivative, trichobotrysin B, was extracted from the ascidian-derived fungus Trichobotrys effusa 4729 (denoted ADFTe4729). There is significant cytotoxicity of trichobotrysin B against glioma proliferation, which triggers apoptosis and cell cycle arrest. Furthermore, studies have found that trichobotrysin B inhibits glioma proliferation in a manner closely related to IL-6-mediated STAT3 phosphorylation and JAK2 activation. In conclusion, this study demonstrates that the small-molecule compound trichobotrysin B inhibits glioma proliferation and induces apoptosis through the IL-6-mediated STAT3/JAK2 signaling pathway, suggesting that trichobotrysin B has potential antiglioma efficiency and provides a new way to explore new small-molecule drugs with anticancer effects. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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