Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

Autor: Karinne Cisne Fernandes Rebouças, José Eleutério Junior, Renata Mírian Nunes Eleutério, Kathiane Lustosa Augusto, Karla Maria Rêgo Leopoldo
Jazyk: English<br />Portuguese
Rok vydání: 2022
Předmět:
Zdroj: DST, Vol 26, Iss 1-4 (2022)
Druh dokumentu: article
ISSN: 2177-8264
Popis: Introduction: The influence of vaginal infections on the natural history of human papillomavirus (HPV) is still unclear. Objective: To determine if patients with low-grade squamous intraepithelial lesions (LSILs) and HPV have more vulvovaginitis than patients with normal liquid-based cervical cytology who were negative for HPV. Methods: This is a cross-sectional study including 322 patients who underwent cervical exams. One hundred and sixty-seven of these patients had LSILs on cervical cytology and were simultaneously hybrid capture 2 (HC2)-positive for HPV, and the remaining 155 patients were negative for malignancies and intraepithelial lesions by cytology and HC2-negative for HPV. The prevalence of vaginal infections in both groups was compared using the χ2 test without Yates’ correction. Results: Among the patients with HPV and LSILs, the most common vaginal infection was vaginosis (8.98%) compared to candidiasis (12.9%) in the patients without LSILs and HPV. No significant differences were found in the prevalence of vaginosis between the two groups (p=0.53). Candidiasis was statistically more prevalent in patients without LSILs and HPV (p
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