Epidrugs: targeting epigenetic marks in cancer treatment
| Autor: | Cristiana Libardi Miranda Furtado, Maria Claudia Dos Santos Luciano, Renan Da Silva Santos, Gilvan Pessoa Furtado, Manoel Odorico Moraes, Claudia Pessoa |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 14, Iss 12, Pp 1164-1176 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2019.1640546 |
| Popis: | Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the epigenetic landscape in the cancer epigenome is one of the most promising target therapies in both treatment and reversibility of drug resistance. Epigenetic alterations in cancer development and progression may be the basis for the individual variation in drug response. Thus, this review focuses on the emerging area of pharmaco(epi)genomics, specifically highlighting epigenetic reprogramming during tumorigenesis and how epigenetic markers are targeted as a therapy (epidrugs) and the clinical implications of this for cancer treatment. |
| Databáze: | Directory of Open Access Journals |
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