| Autor: |
Padmaja Shastri, Justin L. McCarville, Stephen P.J. Brooks, Martin Kalmokoff, Julia M. Green-Johnson |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 20, Iss , Pp 422-432 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2015.11.021 |
| Popis: |
The effect of diets containing different fermentable substrates (resistant starch (RS), oat bran (OB) or wheat bran (WB)) on immune parameters in rat gastrointestinal and systemic tissues under homeostatic immune conditions was examined. Only the diet containing WB altered T and B cell populations in mesenteric lymph nodes (MLN) and spleen. Analysis of tissue cytokine profiles showed ileal cytokine-induced neutrophil chemoattractant (CINC)-1, interleukin 4 (IL-4), IL-10 and transforming growth factor (TGF)-β1 levels increased in rats fed WB, whereas CINC-1, IL-6, and TGF-β1 levels were highest in the colon of OB-fed rats. In the liver, levels of TGF-β1 increased in rats fed diets containing RS or OB. Sex-based differences in immune parameters were observed in rats fed WB. It is apparent that different dietary fermentable substrates have distinct effects on immune activity under homeostatic conditions. These findings provide new insight into immunological outcomes associated with fibres and starches as dietary supplements. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect